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. Author manuscript; available in PMC: 2008 May 30.
Published in final edited form as: Genesis. 2003 Feb;35(2):100–106. doi: 10.1002/gene.10169

FIG. 1.

FIG. 1

K18ires gene constructions. The structures of the K18iresEGFP, K18iresAP, and K18iresCreERT2 transgenes are shown. K18 exons are shown in filled boxes. The locations of Alu sequences are indicated by cross-hatching. The EMCV IRES sequence is indicated by light stippled rectangles. It is inserted downstream of the TGA of exon 7 before the polyadenylation signal (AATAAA), as indicated. The sequences between the last ATG of the IRES element and the initiating codons of the EGFP, AP and CreERT2 genes are shown below the maps.