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. 2008 Jun 11;3(6):e2398. doi: 10.1371/journal.pone.0002398

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Genes that were significantly up-regulated (red) or down-regulated (green) were clustered into a Venn diagram. There were 8 significantly up-regulated and 6 significantly down-regulated genes in the hippocampi collected from HFG male rats compared to the genes from hippocampi collected from control (ad libitum) male rats. Hippocampi collected from HFG female rats showed 7 significantly up-regulated (red) and 7 significantly down-regulated (green) genes compared to the hippocampi collected from control (ad libitum) female rats. There were no significantly up-regulated or down-regulated common genes between male and female rats in this dietary group. Names of the significantly altered genes can be found in Table S1.