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. 2008 Jun 11;3(6):e2398. doi: 10.1371/journal.pone.0002398

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The significantly up-regulated or down-regulated genes that were common between the different dietary regimes. Male hippocampal gene regulation was found to be conserved between the very low energy diet (40% CR) and the high energy (HFG) diet, and interestingly there were no genes in the males that were common between the different energy restriction diets (20% CR, 40% CR, IF). Female hippocampal gene regulation was found to be significantly conserved (70%) between all the energy restriction diets (20% CR, 40% CR, IF), suggesting that female gene regulation is energy intake-specific. Unlike the males, there were no significantly conserved genes between the very low energy diet (40% CR) and the high energy diet (HFG) in the females. *p<0.05, **p<0.01, ***p<0.001.