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. 2008 Jun 11;3(6):e2398. doi: 10.1371/journal.pone.0002398

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Significantly altered genes in the male and female hippocampi from the different dietary regimes were clustered into functional gene pathways. In the hippocampi from male rats on the 40% CR diet, there were 45 significantly altered gene pathways, of which 5 pathways were significantly down-regulated and 40 pathways were significantly up-regulated, compared to gene pathways in hippocampi from male control rats. Interestingly, the hippocampi from female rats on the 40% CR diet showed a very different functional gene pathway pattern as there were 46 significantly altered pathways, of which 22 were significantly down-regulated and 24 were significantly up-regulated, compared to gene pathways in hippocampi from control female rats.