Figure 3. Abnormal Synapses and Rotarod Defect in Bcl-w^−/− Mice.

(A) Electromicrographs of synapses in wild type, Bcl-w^−/−, and Bcl-w^−/−Grid2^{ho−4J(−/−)} mice. Red arrows indicate the normal synapses, light blue arrows the defective synapses with thick postsynaptic density, dark blue arrowheads the synapses with mismatched pre- and post- synaptic elements, black arrows the naked spines, asterisks the swelling Bergmann Glia encompassing Purkinje cells and synapses. (B) The learning profiles as represented by the average retention time for mice to stay on accelerating Rotarod bar during five consecutive testing days. The Bcl-w^−/− mice had significant difference in retention time from that of wild type mice in day 2, 3, 4, and 5, P<0.001.