Table 3.

Effects of local delivery of PDGF and thrombin upon intimal thickening and medial repopulation

Group (n)	I/M*	Significance relative to control†	Number of medial cells/cross section	Significance relative to control‡
Control, 14 days (7)§	1.06  ±  0.12		472  ±  51
PEG-DA, 14 days (7)	0.05  ±  0.02	P  <  0.001	306  ±  22	P  <  0.05
PDGF + PEG-DA, 14 days (7)	0.02  ±  0.01	P  <  0.001	297  ±  40	P  <  0.05
PDGF, 14 days (7)	2.27  ±  0.14	P  <  0.001	495  ±  25	P > 0.4
Thrombin + PEG-DA, 14 days (7)	0.10  ±  0.08	P  <  0.001	282  ±  39	P  <  0.05

Values are mean  ±  SEM. 

^*Ratio of the cross sectional areas of the intima and the media. 

^†By the Mann–Whitney U test. 

^‡Control was injured, not treated with hydrogel barrier, but treated with a perivascular degradable hydrogel containing no protein.