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Voltage ramps to assess the non-inactivating sodium current of LQT mutant sodium channels. Cells were voltage clamped to a holding potential of −120 mV to assure all sodium channels were available to open. The membrane potential was slowly ramped from −120 mV to +40 mV over the course of 2 sec. This slow depolarizing ramp causes inactivation of WT channels, but non-inactivating LQT mutant channels continue to open and reveal the current voltage relationship of these channels.
