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. 2003 Oct 8;100(22):12841–12846. doi: 10.1073/pnas.2134464100

Fig. 6.

Fig. 6.

Site-directed mutagenesis of putative HNF-1 binding sites within the LTR. (A) Mutation of two putative HNF-1 binding sites within the LTR 1–522 reporter construct. Plasmids were transiently transfected into DLD-1 and LoVo cells. Luciferase activities are shown as fold activation as before. Bars represent the mean of four independent transfections ± SEM. H, putative HNF-1 binding site. White type represents mutation of the putative binding site. (B) The sequence of LTR nucleotides 7–47 in each construct is indicated, with mutated nucleotides in uppercase bold type.