Fig. 2.

Effect of doxorubicin treatment on mice lacking STAT3 expression in cardiomyocytes. (A) Left ventricular fractional shortening was measured as described at baseline (D0) and on days 7 (D7) and 11 (D11) after doxorubicin treatment. Summary of mean fractional shortening is by group. *, P < 0.05 vs. F+ on D0. (B) Analysis of fractional shortening in knockout (C/F/D) and heterozygote (C/F/+) animals initially matched for left ventricular function over a 12-day time course after injection of doxorubicin. *, P = not significant for C/F/D vs. C/F/+ on days 0 and 3; †, P < 0.01 for C/F/D vs. C/F/+ on days 7 and 12.