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Mice lacking cardiac STAT3 develop severe cardiac fibrosis with advanced age. (A) Cardiac tissues from 6-month-old mice were examined by trichrome blue staining. Tissue from cardiac STAT3 null mice (C/F/D) (Top) and control mice [heterozygous C/F/+ (Middle) or WT F/+ mice (Bottom)]. (B) Similar staining was done with 9-month-old mice. (Magnification: ×20.)
