Fig. 3.
Snm-mediated secretion is required for M. tuberculosis virulence. (A) C57BL/6 mice were injected with 1 × 106 cfu of each strain, and bacilli were harvested from lungs at 1, 5, 10, 15, and 21 d after infection. Error bars represent the SEM from two combined experiments by using five mice per timepoint per experiment. (B) cfu data from A normalized to initial inoculum (see Materials and Methods). (C) cfu isolated from spleens of mice infected in A.(D) cfu data from C normalized to initial inoculum. (E) Survival of BALB/c mice (n = 15 per group) infected with 106 cfu of indicated strains.