Table 2. Average physiological parameters measured before, during, and after MCA occlusion surgery in subset of animals.
| pH | pCO2, mmHg | pO2, mmHg | BP (mean), mmHg | Temperature, °C | % Decrease in CBF | |
|---|---|---|---|---|---|---|
| WT (n = 4) | ||||||
| Before occlusion | 7.4 ± 0.02 | 29.4 ± 3.0 | 179.0 ± 15.9 | 78.3 ± 4.3 | 37.2 ± 0.2 | |
| During occlusion | 7.38 ± 0.02 | 33.3 ± 1.7 | 165.3 ± 13.3 | 79.3 ± 5.4 | 37.0 ± 0.1 | 80.1 ± 3.4 |
| After occlusion | 7.34 ± 0.02 | 38.6 ± 3.2 | 151.0 ± 11.7 | 73.8 ± 4.3 | 36.9 ± 0.1 | |
| PAR1-/- (n = 4) | ||||||
| Before occlusion | 7.38 ± 0.01 | 32.0 ± 2.2 | 166.6 ± 15.8 | 84.5 ± 6.3 | 36.9 ± 0.1 | |
| During occlusion | 7.35 ± 0.04 | 33.3 ± 4.9 | 159.8 ± 23.1 | 85.0 ± 8.3 | 36.9 ± 0.2 | 78.4 ± 2.3 |
| After occlusion | 7.33 ± 0.04 | 34.3 ± 2.6 | 163.7 ± 15.8 | 69.0 ± 9.7 | 37.1 ± 0.2 |
Cerebral blood flow (CBF) measurements were recorded 5 min after MCA occlusion. There were no statistically significant differences (ANOVA) in any of the parameters between PAR1-/- and WT mice. 1 mmHg = 133 Pa.