TABLE 3.
Distribution of brain leukocyte infiltrates in the experimental groups. Leukocyte infiltration visualized with the panleukocyte marker (CD 45) in several brain levels and the spinal cord. -: absence of leukocytes; +: low density of leukocytes; +++: high density of leukocytes; B: Bregma level corresponding to the stereotaxic atlas of Paxinos and Watson (1982); CNS: Central Nervous System; S: scarce distribution (only in some regions); W: widespread distribution in different regions of the level marked.*: region not studied in this experiment.
| GROUP | ||||||
|---|---|---|---|---|---|---|
| CNS LEVEL | EAE RATS treated with GEMSP | NON-EAE RATS treated with NaCl | EAE RATS treated with NaCl | |||
| D 15 | D 24 | D 60 | D 100 | |||
| B - 0.2 to B - 0.3 | - | - | +++/W | +/W | - | - |
| B - 0.3 to B - 0.8 | - | - | +++/W | +/W | +/S | - |
| B - 1.3 | - | - | +++/W | * | +/S | - |
| B - 2.8 | +/S | - | +++/W | +/W | - | - |
| B - 3.3 | - | - | +++/W | * | - | - |
| B - 3.3 to B - 3.8 | +/S | - | +++/W | * | - | - |
| B - 10.8 | - | - | +++/W | +/W | - | - |
| B - 11.3 to B - 11.8 | - | - | +++/W | +/W | - | |
| B - 14.3 | - | - | +++/W | +/W | - | +/S |
| Spinal Cord | - | - | * | * | +/S or +++/S | +/S |