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. 2008 Jun;172(6):1580–1590. doi: 10.2353/ajpath.2008.071021

Figure 5.

Figure 5

IGF-II induces collagen type I and fibronectin production in a time-dependent manner in primary lung fibroblasts from SSc (A) and normal lungs (B). Equal numbers of SSc and normal fibroblasts were cultured in media with or without IGF-II (200 ng/ml) for 24 to 72 hours. C: Both SSc and normal fibroblasts secreted significantly increased amounts of collagen throughout time compared to media alone. D: Only SSc fibroblasts showed significant fibronectin production at 48 hours. Data represent four different SSc and four different normal fibroblasts. Asterisk denotes P < 0.05.