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IGF-II does not induce fibroblast proliferation. SSc and normal lung fibroblasts were treated with IGF-II for a total of 48 hours and proliferation measured using 3H-thymidine incorporation. SSc and normal fibroblasts do not show a statistically significant increase in proliferation using different IGF-II concentrations. Data are shown as a ratio of IGF-II stimulated to unstimulated fibroblast proliferation.
