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. 2008 Jun;172(6):1591–1602. doi: 10.2353/ajpath.2008.071067

Figure 1.

Figure 1

G-EAT resolution is inhibited in CD8-depleted WT and IL-10−/− recipients. G-EAT severity scores of individual mice 20 and 60 days after cell transfer are shown. Control: WT (donor) to WT (recipient); anti-CD8: WT (donor) to WT (recipient) given anti-CD8; IL-10−/−: IL-10−/− (donor) to IL-10−/− (recipient). A: Thyroid lesions in all groups reached maximal severity 20 days after cell transfer, and disease severity scores were similar with an average score of 3.3 to 4.0. B: By day 60, thyroid lesions in CD8-depleted WT and IL-10−/− recipients had ongoing inflammation (average severity score, 3.8 to 4.1), whereas thyroid lesions in WT controls had begun to resolve (average severity score, 1.2). Results are pooled from two separate experiments and are representative of five experiments. A significant difference between CD8-depleted WT and IL-10−/− recipients versus WT controls is indicated by the asterisk (P < 0.001).