Table 2.

Macaque Experimental Parameters

Macaque no.	Species	Age at death (months)	Sex	Disease at time of sacrifice	Length of infection (days)	PET scan dates (days after infection)	Neuropathological diagnosis
CW06-280	Pigtailed	74	M	AIDS	174	0, 65, 100, 142, and 164	SIVE
CW06-282	Pigtailed	81	M	AIDS	42	0 and 42	SIVE
CW06-285	Pigtailed	93	M	AIDS	51	0 and 51	SIVE
CW06-286	Pigtailed	82	M	AIDS	51	0 and 51	SIVE
CW06-288	Pigtailed	83	M	AIDS	101	0, 51, 79, and 101	SIVE
CW06-289	Pigtailed	75	M	AIDS	128	0, 50, 99, and 120	SIV, no encephalitis
CW06-292	Pigtailed	81	M	AIDS	119	0, 50, and 106	SIV, no encephalitis

Seven pigtail macaques infected with SIV were imaged with three-dimensional PET using [¹¹C](R)-PK11195 longitudinally at the indicated time points in column 7. When macaques progressed to AIDS, they were sacrificed, after which they were grouped into SIVE or SIV infected, without encephalitis (SIV no E) categories based on the histopathology (frequency of distribution of multinucleated giant cells, microglial nodules, abundant activated and SIV-infected macrophages, perivascular chronic inflammation per ×10 and ×40 field in different brain regions).