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. 2008 Jun;172(6):1617–1624. doi: 10.2353/ajpath.2008.070971

Figure 3.

Figure 3

Effect of the D1R antagonists on meth-mediated up-regulation of HIV Bal infection. Seven-day-cultured macrophages were incubated with or without the D1R antagonist, 10 μmol/L SCH23390, or 10 μmol/L SKF83566 for 1 hour before treatment with or without 100 μmol/L meth for 24 hours and then infected with HIV Bal strain for 2 hours in the presence or absence of meth and/or SCH23390 or SKF83566. Culture supernatants were collected at day 8 after infection for HIV RT assay. Data are expressed as HIV RT activity in meth-treated cells (percentage of control) to those in untreated cells, which is defined as 100%. The results represent the mean ± SD of three independent experiments. Statistical analysis was performed using one-way analysis of variance, and significance is shown with *P < 0.05 and **P < 0.01 (METH + SCH or METH + SKF versus METH).