Table 1.
Case Information for Synaptosome Samples
| No. | Sex | Age (years) | PMI (h) | Braak & Braak score | Frontal cortex atrophy | Neuritic plaques | Neurofib. changes (neuropil threads) | Amyloid fluor. in terminals (RFU) | p-tau fluor in terminals (RFU) |
|---|---|---|---|---|---|---|---|---|---|
| Normals | |||||||||
| 726 | F | 97 | 5.5 | — | Mild | 0 | 0 | 20.29 | 23.89 |
| 758 | M | 93 | 8.5 | Mild | Sparse | 0 | 50.1 | 30.4 | |
| PD only | |||||||||
| 711 | M | 74 | 7.8 | PD | Mild | Sparse | Sparse | 44.7 | 33.8 |
| 720 | M | 63 | 3.5 | PD | Mild | Sparse | Sparse | 66.5 | 25.18 |
| Dementia | |||||||||
| AD cases | |||||||||
| 024 tauopathy | F | 72 | 5 | Prom | 0 | Marked | 58.7 | 137.3 | |
| 730 AD def | F | 76 | 3.6 | VI | Severe | Sparse | Sparse | 96.3 | 79.0 |
| 716 AD def | F | 86 | 5 | VI | Severe | Mod | Mod | 97.3 | 58.7 |
| 731 AD def | F | 87 | 5.3 | V to VI | Mild | Mod | Sparse | 107.5 | 73.3 |
| 721 AD def | F | 87 | 5 | VI | Mild | Freq | Mod | 113.8 | 88.8 |
| 738 AD def+PD | M | 83 | 11 | V | Mod | Mod | 0 | 118.1 | 43.2 |
| 752 AD prob | M | 98 | 5.83 | III to V | Mod | Mod | 0 | 134.15 | 24.91 |
| 745 AD def | F | 92 | 4.75 | V | Mild | Mod | Sparse | 155.4 | 52.13 |
| 722 AD poss | M | 88 | 6 | Mild | Sparse | Sparse | 186.3 | 67.5 | |
| PD + dementia | |||||||||
| 735 AD poss no clinical dementia | M | 82 | 4 | IV | Mild | Mod | 0 | 203.5 | 83.1 |
| 718 AD def | M | 83 | 7 | V | Mild | Freq | Mod | 232.8 | 94.8 |
Neuropil threads and plaques are reported for frontal cortex and refer to silver (Gallyas) stain. The plaque number includes plaques with and without cores: sparse (<5/field), mod (6 to 20/field), freq (21 to 30/field). RFU, mean relative fluorescence for Aβ and p-tau antibody fluorescence measured by flow cytometry (mean value includes frontal, superior parietal, and parietal (A39 and A40) cortex, hippocampus, entorhinal cortex, and cerebellum).