Table 2.
Maximal force of contraction of soleus muscle during electrical stimulation of muscle or nerve
| Stimulation | force (mN)
|
|||
|---|---|---|---|---|
|
AChRɛ+/−
|
AChRɛ−/−
|
|||
| Muscle | Nerve | Muscle | Nerve | |
| Twitch | 28.7 | 28.7 | 20.4 | 20.4 |
| 20 Hz | 125 | 125 | 119 | 112 |
| 100 Hz | 168 | 167 | 154 | 126 |
| Twitch/dTC | 27.5 | 27.5 | 14.4 | 13.7 |
| 20 Hz/dTC | 130 | 130 | 83.7 | 43.1 |
| 100 Hz/dTC | 172 | 168 | 116 | 62 |
Contraction force measurements on three soleus muscles (P32) of heterozygous (AChRɛ+/−) or null mutant mice (AChRɛ−/−) in normal Tyrode solution and in blocking solution [Tyrode solution containing in addition 0.1 μM (+)-tubocurarine, (dTC)] at 25°C. Force refers to mean maximal amplitude of contraction force measured during direct electrical stimulation of the muscles or during electrical stimulation of the ischiadic nerve.