Table 1.

A 4-day suppressive test of aqueous leaf extracts of Vernonia amygdalina in Plasmodium berghei (ANKA) infected mice.

		Plasmodium berghei infection
	P. bergheiS.		P.bergheiR.
Prophylactic experiment	Parasitaemia	Suppression (%)	Parasitaemia	Suppression (%)
	(%rbc)		(%rbc)
Group 1
Uninfected (Control)	-	-	-	-
Group 2
CQ (5kg/kg)	5.52 ± 1.19	72.70	9.16 ± 0.9a	57.20
Group 3
V31.75	13.73 ± 1.30	32.10	13.77 ± 1.52	35.65
V62.5	10.34 ± 0.39	48.86	10.71 ± 0.11	49.95
V125	7.93 ± 0.29	50.78	7.99 ± 0.32	62.66
Group 4
CQ5+V31.75	8.67 ± 0.22	57.12	9.12 ± 0.64a	57.38
CQ5+V62.5	6.83 ± 0.42	66.22	6.87 ± 0.23	67.90
CQ5+V125	4.17 ± 0.21	79.37	4.13 ± 0.10	80.71
Group 5
†Infected Control	20.22 ± 0.73	-	21.40 ± 0.22	-

Data are expressed as mean ± SEM of at least four mice per group or subgroup and analyzed by ANOVA

^†The day 4 survival rates among the P. berghei infected control (Group 5) were 83.3 % (P. berghei^S) and 75% (P. berghei^R) respectively. CQ5 = Chloroquine at 5mg/kg dose; Vernonia amygdalina leaf extract given at doses of 31.75, 62.5 and 125 mg/kg are indicated as V31.75, V62.5 and V125 respectively.

^aP < 0.05 (P. berghei^S vs. P. berghei^R). P < 0.05 was considered significant.