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. 2008 Mar;8(1):25–35.

Table 4.

Toxicity testing of Vernonia amygdalina leaf extracts and chlopheniramine in mice.

Biochemical parameter (IU/L)
#Drug group sGPT (%) sGOT (%) LDH (%)
Control 32.8 ± 2.4 - 40.1 ± 3.8 - 114.2 ± 8.7 -
CQ (10mg/kg) 37.2 ± 3.1a 13.4 49.6 ± 2.4a 23.6 116.7 ± 10.3. 2.2
V31.75 33.8 ± 2.4 3.0 43.5 ± 2.1 8.5 117.3 ± 13.2 2.7
V62.5 36.4 ± 2.4a 11.0 47.8 ± 3.8a 19.2 121.7 ± 3.1a 6.6
V125 43.9 ± 4.2b 33.8 48.2 ± 2.1a 20.1 127.6 ± 4.2a 11.7
CQ10+V31.75 47.5 ± 5.3a 44.8 53.8 ± 7.2a 34.2 138.5 ± 6.2a 21.3
CQ10+V62.5 54.5 ± 3.5c 66.2 59.4 ± 1.7a 48.1 171.8 ± 5.3b 50.4
CQ10+V125 68.2 ± 6.1c 107.9 84.7 ± 5.2b 111.2 213.6 ± 8.1c 87.0
CQ10+CP0.25 47.3 ± 2.8b 44.2 58.7 ± 3.1a 46.4 165.3 ± 6.2b 44.7

Data are expressed as mean ± SEM of five mice per group and analyzed using ANOVA.

#

No deaths of the drugged and undrugged mice occurred by day 8. Different superscripted letters indicate significant difference (P < 0.05) between data. % = Percentage increase in enzyme activity in international units (IU) per litre (L).

abc

P < 0.05. sGOT = serum glutamate oxaloacetate transaminase; sGPT = Serum glutamate pyruvate transaminase; LDH = Lactate dehydrogenase.