Table 4.
Toxicity testing of Vernonia amygdalina leaf extracts and chlopheniramine in mice.
| Biochemical parameter (IU/L) | ||||||
| #Drug group | sGPT | (%) | sGOT | (%) | LDH | (%) |
| Control | 32.8 ± 2.4 | - | 40.1 ± 3.8 | - | 114.2 ± 8.7 | - |
| CQ (10mg/kg) | 37.2 ± 3.1a | 13.4 | 49.6 ± 2.4a | 23.6 | 116.7 ± 10.3. | 2.2 |
| V31.75 | 33.8 ± 2.4 | 3.0 | 43.5 ± 2.1 | 8.5 | 117.3 ± 13.2 | 2.7 |
| V62.5 | 36.4 ± 2.4a | 11.0 | 47.8 ± 3.8a | 19.2 | 121.7 ± 3.1a | 6.6 |
| V125 | 43.9 ± 4.2b | 33.8 | 48.2 ± 2.1a | 20.1 | 127.6 ± 4.2a | 11.7 |
| CQ10+V31.75 | 47.5 ± 5.3a | 44.8 | 53.8 ± 7.2a | 34.2 | 138.5 ± 6.2a | 21.3 |
| CQ10+V62.5 | 54.5 ± 3.5c | 66.2 | 59.4 ± 1.7a | 48.1 | 171.8 ± 5.3b | 50.4 |
| CQ10+V125 | 68.2 ± 6.1c | 107.9 | 84.7 ± 5.2b | 111.2 | 213.6 ± 8.1c | 87.0 |
| CQ10+CP0.25 | 47.3 ± 2.8b | 44.2 | 58.7 ± 3.1a | 46.4 | 165.3 ± 6.2b | 44.7 |
Data are expressed as mean ± SEM of five mice per group and analyzed using ANOVA.
#
No deaths of the drugged and undrugged mice occurred by day 8. Different superscripted letters indicate significant difference (P < 0.05) between data. % = Percentage increase in enzyme activity in international units (IU) per litre (L).
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P < 0.05. sGOT = serum glutamate oxaloacetate transaminase; sGPT = Serum glutamate pyruvate transaminase; LDH = Lactate dehydrogenase.