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. 2008 Jun 6;4(6):e1000088. doi: 10.1371/journal.pgen.1000088

Figure 8. DSB Repair Proteins are Required for the Polymerization of Central Region Components of the SC Along Chromosome Axes in cra-1 Mutants.

Figure 8

(A–F) High magnification images of late pachytene nuclei from age-matched cra-1; mre-11, cra-1; rad-51 and cra-1; msh-5 mutant hermaphrodites which have not been irradiated (A, C, E), and 8 hours post-irradiation (B, D, F). SYP-1 aggregates are observed in cra-1; mre-11, cra-1; rad-51 and cra-1; msh-5 double mutants (A, C, E), suggesting that DSB repair proteins are required to prevent SYP-1 aggregation. Introducing exogenous DSBs does not alleviate this phenotype (B, D, F). Nuclei are co-stained with DAPI (blue) and anti-SYP-1 (red). Bars, 2 µm.