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. 2008 Jun 4;3(6):e2363. doi: 10.1371/journal.pone.0002363

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Cohen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The proportion of resistance among incident cases included in surveys (y-axis for all subplots) is graphed against the actual proportion of incident disease which is drug-resistant (x-axis for subplots A, C, E, and G) and against the actual proportion of prevalent disease which is drug-resistant (x-axis for subplots B,D,F, and H). The insets for subplots A–D show the fraction by which the proportion of TB which is DR is underestimated by the survey (y-axis) plotted by the true proportion which is resistant (x-axis). Subplots show the relationship between the surveyed and actual proportions of TB that is resistant during early (A,B) and later periods (C–H) of DR TB epidemics. Three different scenarios are depicted for later periods: no additional interventions to control DR TB (C,D), interventions which limit acquired drug resistance (E,F), and interventions which improve treatment of drug-resistant disease (G,H).