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A reduced map of the MHC illustrating clustering of immune system genes. Two kinds of gene clustering are apparent. First, sequence-related duplicates that have allowed diversification of duplicates, e.g. HLA or C4 complement genes. Second, sequence unrelated genes with related immune function, e.g. PSMB8/9 — proteosome components, TAP1/2 — peptide transporters, TAPBP — peptide chaperone, and HLA — peptide presentation.
