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. 2008 Jun;35(3):179–192. doi: 10.1111/j.1744-313X.2008.00765.x

Figure 4.

Figure 4

A shared ancestral block between two DR3 -DQ2 MHC haplotypes. The COX and QBL haplotypes share an ~158 kb ancestral block, which contains the HLA-DRB2, HLA-DRB1, HLA-DQA1, HLA-DQB1 and MTCO3P1 loci. Within this block there are only 14 single nucleotide polymorphisms (SNPs) distinguishing the two DR3-DQ2 haplotypes, whereas there are 3808 SNPs that differ between the DR3-DQ2 haplotypes and the DR15-DQ6 haplotype (PGF). This difference can be calculated to correlate with ~3400 generations that elapsed since the two DR3-DQ2 haplotypes separated vs. greater than 20 million years that separate the DR15-DQ6 haplotype from the DR3-DQ2 haplotypes. Vertical lines represent SNPs. HLA types for each haplotype are shown.