Figure 2.

 Cerulenin inhibits MM cell growth. (A) Chemical structure of Cerulenin. (B) MM.1S (), MM.1R (□), U266 (), RPMI8226. (•), RPMI LR5 (○), RPMI Dox40 (◆), OPM1 (⋄) and OPM2 (*) cells were cultured for 24 or 48 h in the presence of Cerulenin. (C) IC₅₀ of MM cell lines treated with Cerulenin for 24 or 48 h. (D) Cerulenin inhibits growth of primary MM patient cells [#1 (), #2 (□), #3 (), n = 3]. (E) Cerulenin does not affect viability of PBMNC derived from three healthy volunteers [#1 (), #2 (□), #3 (), n = 3]. (F) Cerulenin does not affect viability of plasma cells derived from three healthy volunteers [#1 (), #2 (□), #3 (), n = 3]. Cell growth was assessed by MTT assay (B, C, D, E, F), and data represent mean ± SD of triplicate cultures.