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. Author manuscript; available in PMC: 2008 Jun 1.
Published in final edited form as: Magn Reson Med. 2004 Dec;52(6):1234–1238. doi: 10.1002/mrm.20291

FIG. 1.

FIG. 1

Coronal maximum intensity projections from three-dimensional data sets of diffusion-weighted images obtained from a normal adult receiving granulocyte colony-stimulating factor prior to stem cell harvest and donation to a sibling with leukemia: (a) Day 0 and (b) Day 5 of G-CSF administration. The signal from bone marrow in the axial skeleton is markedly increased, consistent with a change in both the apparent water fraction, from 0.44 ± 0.06 to 0.69 ± 0.04, and the T2 value of water in the marrow, from 43.7 ± 5.4 to 58.4 ± 4.9 msec. The spleen also increased in size, from 238 to 493 mm3. The white blood cell count underwent a sevenfold increase over the same time period. The results are consistent with bone marrow mobilization.