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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Neurobiol Aging. 2007 Feb 8;29(6):836–847. doi: 10.1016/j.neurobiolaging.2006.12.018

Figure 2.

Figure 2

Enhancement of in vivo plaque detection following intracarotid injection of Gd-DTPA-K6Aβ1–30 with mannitol in 20 month old Tg2576 mouse. (A) A few large plaques can be visualized in the pre-ligand scan and their detection is likely related to high iron content in Aβ plaques in older mice (see Figure 3). (B) Following intracarotid injection of Gd-DTPA-K6Aβ1–30, the number of visualized plaques is substantially increased, and these plaques co-register with plaques detected with 6E10 antibody on histological sections as depicted in C.