Table 1.
Studied ages and weights of PDAPP homozygotes, heterozygotes and littermate controls.
| Wildtype | Heterozygotes | Homozygotes | |
|---|---|---|---|
| 2 Month-old | N = 8 | N = 7 | N = 8 |
| age (days) | 58.5 ± 0.9 | 55.6 ± 3.3a | 52.3 ± 1.0 ab |
| weight (g) | 34.2 ± 2.7 | 31.0 ± 4.1 | 30.6 ± 2.4 a |
| 12 Month-old | N = 8 | N = 8 | N = 7 |
| age (days) | 374.0 ± 1.1 | 373.8 ± 1.0 | 374.4 ± 1.0 |
| weight (g) | 42.2 ± 3.0 | 41.2 ± 3.4 | 36.3 ± 2.5 ab |
Superscripts indicate statistically significant (but likely not meaningful) differences across transgene dose (Student’s t-tests, with α = 0.05)
a
significantly different from same-aged WT
b
significantly different from same-aged heterozygote.