Table 2.

FDG uptake in control and cingulate regions.

	2-Month-Old				12-Month-Old				ANOVA P
	WT	+/−	+/+	tauP	WT	+/−	+/+	tauP	Dose	Age	Int
Optic tract	244 ± 94	300 ± 100	282 ± 95	0.573	337 ± 113	251 ± 73	314 ± 78	0.778	0.800	0.365	0.119
Whole brain	493 ± 113	560 ± 187	506 ± 126	0.778	663 ± 127	519 ± 143	561 ± 110	0.159	0.635	0.155	0.088
Whole brain / Optic tract	2.34 ± 1.23	1.93 ± 0.21	1.86 ± 0.29		2.12 ± 0.71	2.10 ± 0.39	1.81 ± 0.16		0.227	0.870	0.688
Cingulate gyrus, retrosplenial	1207 ± 107	1073 ± 114	1003 ± 79 a	0.002	1160 ± 71	1086 ± 98	1049 ± 54a	0.011	<0.001	0.883	0.350
Cingulate gyrus, posterior 2	1265 ± 50	1210 ± 102	1097 ± 91 a	0.002	1257 ± 86	1224 ± 109	1106 ± 74 a	0.007	<0.001	0.835	0.938
Cingulate gyrus, posterior	1249 ± 35	1294 ± 58	1214 ± 60	0.284	1249 ± 77	1281 ± 45	1160 ± 71 b	0.071	<0.001	0.211	0.424
Cingulate gyrus, middle	1185 ± 40	1250 ± 56	1204 ± 68	0.416	1257 ± 85	1264 ± 54	1193 ± 76	0.128	0.063	0.208	0.208
Cingulate gyrus, anterior	1079 ± 44	1061 ± 67	1112 ± 88	0.260	1071 ± 59	1110 ± 47	1075 ± 58	1.00	0.705	0.928	0.168

FDG uptake mean ± standard deviation from wildtype (WT), heterozygous (+/−), and homozygous (+/+) PDAPP mice, along with P values from the Kendall’s tau and omnibus F-tests. There were no statistically significant interactions (Int) between transgene dose and age. Superscripts indicate significant post hoc results across transgene dose (Student’s t-tests, with reduced α = 0.01)

^asignificantly different from same-aged WT

^bsignificantly different from same-aged heterozygote. Retrosplenial and posterior cingulate activity declines in significant correlation to gene dose, but not age. Region labels correspond to the stereotaxic atlas of Paxinos and Franklin (2001), except cingulate gyrus was subdivided as follows: middle—Bregma −0.5; posterior—Bregma −1.4; posterior 2—Bregma −2.1; retrosplenial—Bregma −2.6.