Table 3.

FDG uptake in additional cortical and subcortical regions.

	2-Month-Old				12-Month-Old				ANOVA P
	WT	+/−	+/+	tauP	WT	+/−	+/+	tauP	Dose	Age	Int
Posterior parietal cortex	1061 ± 73	1045 ± 68	1071 ± 83	0.612	1103 ± 62	1145 ± 79	1117 ± 62	0.652	0.855	0.005	0.472
Primary somatosensory cortex	1059 ± 54	1106 ± 56	1142 ± 57 a	0.003	1080 ± 80	1137 ± 54	1149 ± 65	0.024	0.004	0.273	0.866
Primary somatosensory, barrels	1124 ± 115	1126 ± 77	1212 ± 52	0.955	1105 ± 52	1125 ± 63	1140 ± 76	0.215	0.070	0.179	0.429
Secondary somatosensory c.	1101 ± 96	1084 ± 83	1126 ± 50	0.430	1057 ± 52	1084 ± 95	1104 ± 77	0.284	0.391	0.351	0.729
Primary visual c., monocular	1034 ± 80	976 ± 80	1037 ± 99	0.822	1020 ± 81	1071 ± 126	1049 ± 64	0.367	0.817	0.260	0.241
Primary visual c., binocular	1037 ± 75	974 ± 86	1038 ± 94	0.236	1025 ± 97	1060 ± 147	1065 ± 68	0.236	0.642	0.254	0.396
Secondary visual cortex	1029 ± 78	954 ± 74	1051 ± 61	0.910	1021 ± 103	1028 ± 177	1066 ± 84	0.499	0.224	0.384	0.537
CA1	756 ± 40	761 ± 26	796 ± 42	0.143	742 ± 41	791 ± 47	850 ± 47 a	0.001	<0.001	0.064	0.075
CA3	738 ± 20	707 ± 39	746 ± 50	0.778	751 ± 35	752 ± 57	789 ± 39	0.128	0.055	0.010	0.511
Dentate gyrus	872 ± 37	854 ± 70	871 ± 48	0.822	888 ± 26	889 ± 47	919 ± 28	0.130	0.373	0.018	0.617
Subiculum	883 ± 36	922 ± 36	895 ± 52	0.430	906 ± 40	936 ± 60	909 ± 29	0.693	0.088	0.194	0.949
Anteroventral thalamus	893 ± 64	926 ± 100	916 ± 64	0.430	947 ± 112	922 ± 139	945 ± 112	1.00	0.962	0.384	0.738
Reticular thalamus	913 ± 45	965 ± 50	955 + 43	0.091	956 ± 53	953 ± 54	971 ± 35	0.735	0.202	0.272	0.291
Paratenial thalamus	988 ± 88	992 ± 83	993 + 62	0.866	1080 ± 68	1018 ± 50	1023 ± 63	0.128	0.456	0.022	0.347
Reuniens thalamus	778 ± 53	770 ± 34	824 + 68	0.236	848 ± 59	857 ± 77	839 ± 53	0.955	0.625	0.002	0.240
Ventromedial thalamus	1199 ± 55	1185 ± 50	1194 ± 62	0.955	1229 ± 79	1184 ± 43	1179 ± 77	0.159	0.336	0.798	0.598
Ventrolateral thalamus	1252 ± 63	1203 ± 75	1240 ± 71	0.822	1223 ± 53	1203 ± 31	1205 ± 66	0.735	0.315	0.237	0.693
Lateral posterior thalamus	1078 ± 45	1052 ± 63	1027 ± 69	0.236	1108 ± 66	1093 ± 66	1063 ± 47	0.215	0.098	0.053	0.966
Parafascicular thalamus	1074 ± 87	1123 ± 97	1027 ± 81	0.573	1095 ± 53	1117 ± 74	1082 ± 72	0.778	0.081	0.318	0.565
Lateral habenula	886 ± 96	966 ± 62	894 ± 120	0.910	928 ± 107	930 ± 92	941 ± 62	0.693	0.461	0.531	0.407
Paraventricular hypothalamus	648 ± 40	615 ± 42	678 ± 45	0.215	701 ± 23	687 ± 60	729 ± 70	0.464	0.018	<0.001	0.821
Rostral caudoputamen	1029 ± 63	1132 ± 94	1104 ± 83	0.114	999 ± 25	1058 ± 79	1133 ± 86 a	0.001	0.001	0.263	0.171
Caudal caudoputamen	760 ± 102	656 ± 68	755 ± 92	1.00	694 ± 41	633 ± 81	806 ± 78 ab	0.055	<0.001	0.602	0.133
Subthalamus	914 ± 46	969 ± 77	904 ± 41	0.778	934 ± 55	934 ± 103	918 ± 62	0.778	0.251	0.980	0.466
Zona inserta	925 ± 65	949 ± 62	957 ± 47	0.195	1007 ± 64	960 ± 87	964 ± 78	0.195	0.900	0.111	0.238
Nucleus accumbens	917 ± 71	853 ± 82	918 ± 84	1.00	870 ± 77	830 ± 76	935 ± 55 b	0.114	0.013	0.428	0.501
Nuc. of vertical diagonal band	832 ± 27	812 ± 72	855 + 53	0.612	864 ± 69	851 ± 92	867 ± 65	0.778	0.483	0.169	0.839
Anterior pretectal area, dorsal	1139 ± 67	1207 ± 35	1138 ± 41 b	0.114	1159 ± 35	1153 ± 90	1100 ± 42 a	0.081	0.018	0.155	0.161
Anterior pretectal area, ventral	1185 ± 65	1230 ± 80	1134 ± 41 b	0.260	1143 ± 37	1164 ± 73	1110 ± 59	0.398	0.006	0.018	0.639
Dorsolateral geniculate	936 ± 41	884 ± 39	880 ± 54	0.091	922 ± 53	873 ± 51	896 ± 39	0.499	0.011	0.841	0.622
Superior colliculus, deep gray	892 ± 51	890 ± 72	888 ± 35	0.236	849 ± 61	864 ± 61	849 ± 61	0.955	0.909	0.041	0.907
Superior colliculus, superf. gray	952 ± 83	932 ± 122	895 ± 74	0.195	952 ± 77	946 ± 100	914 ± 71	0.338	0.327	0.678	0.950
Red nucleus	1060 ± 58	1133 ± 96	1065 ± 51	0.866	1039 ± 52	1052 ± 83	1052 ± 47	0.535	0.185	0.061	0.321
Nucleus of III	1129 ± 58	1177 ± 70	1115 ± 62	0.215	1120 ± 52	1133 ± 129	1091 ± 68	0.535	0.198	0.263	0.822
Pontine nuclei	885 ± 68	940 ± 60	908 ± 41	0.284	836 ± 47	889 ± 66	908 ± 49	0.024	0.022	0.053	0.383
Inferior colliculus, central	1360 ± 196	1299 ± 279	1409 ± 145	0.430	1072 ± 344	964 ± 145	987 ± 122	0.955	0.541	<0.001	0.695
Periaqueductal gray	697 ± 90	744 ± 92	738 ± 40	0.003	720 ± 74	732 ± 67	754 ± 80	0.338	0.362	0.693	0.791

Listing of additional regions analyzed and FDG uptake mean ± standard deviation from wildtype (WT), heterozygous (+/−), and homozygous (+/+) PDAPP mice, along with P values from the Kendall’s tau and omnibus F-tests. There were again no statistically significant interactions (Int) between transgene dose and age. Superscripts indicate significant post hoc results across transgene dose (Student’s t-tests, with reduced α = 0.01)

^asignificantly different from same-aged WT

^bsignificantly different from same-aged heterozygote. Region labels correspond to the stereotaxic atlas of Paxinos and Franklin (2001).