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The effect of decreasing the Ca2+/Mg2+ ratio on frequency facilitation at Schaffer collateral/com synapses. Decreasing the Ca2+/Mg2+ ratio reduced the slope of the fEPSP by 93 ± 0.6%, increased the PPF to 231 ± 53%, and increased the frequency facilitation by 55 ± 14% (n = 6). Voltage traces: Superimposed fEPSPs collected at two different frequencies. The experiments were performed in the presence of d-2-amino-5-phosphonovaleric acid (50 μM).
