Table 1.

Recently Reported Studies of Growth During Stimulant Treatment ^a

Study	N	Age (years)	Drug	Doseb	Duration	Design	Findings
Kramer et al., 200022	97	4-12	MPHc	10-40 mg	36 months	Retrospective	Adult height and weight not affected
Sund & Zeiner, 200223	91	3-10	MPH AMPd	24 mg 12 mg	12 month	Observational	Smaller weight growth on AMP
Lisska & Rivkees, 200324	84	-	MPH	22 mg	24 months	Observational	Decrease in height z scores
Poulton & Cowell, 200325	51	3-11	MPH AMP	27 mg 14 mg	42	Observational	1 cm/year an 1.2 kg less than expected
Biederman et al., 200326	124	6-17	Multiple	Unspecified	Unspecified	Observational	No treatment effect on growth
MTA Cooperative, 200427	579	7-10	MPHe	0-39 mgf	14 months	Randomized	1.23 cm/year and 2.48 kg/year less growth
Faraone et al., 200529	569	6-12	AMP-XR	10-30 mg	6-30 months	Observational	Decrease in height (-0.31) and weight (-0.63) z scores
Spencer et al., 200630	178	6-13	OROS MPH	1.2 mg/kg 43.7 mg	21 months	Observational	0.23 cm less than expected 1.23 kg less than expected No change in mean z scores
Pliszka et al., 200631	113 66	8.5 (mean) 9.0 (mean)	MPH AMP	34.8 22.7	32 months 29 months	Retrospective	No change in mean z scores
Charach et al., 200632	79	6-12	MPH or AMP	unspecified	60 months	Observational	Dose dependent decrease in height and weight z scores.
Zachor et al., 200633	81	8.5 (mean)	MPH or AMP	unspecified	36 months	Retrospective	Decrease in z scores for weight but not for height
Swanson et al. 200620	95	3-5	MPH	14.2 mg	12 months	Observational	1.4 cm/year less than expected 1.3 kg/yr less than expected 0.30 decrease in height z 0.53 decrease in weight z
Swanson et al. 200721, h	320	7-10	MPH	unspecified	36 months	Observational	Dose related decrease in height and weight z scores. Consistently medicated children were 2.3 cm shorter and 1.5 kg lighter than normal controls
Farietta-Murray, 2007	50	4-10	MPH AMP	unspecified	24 months	Retrospective	Decrease in weight percentile only

^aIncluded were studies of at least 50 children and of at least 12 month duration

^bHighest mean daily dose

^cMPH: methylphenidate

^dAMP: amphetamine

^eA few children received dextroamphetamine or other medications.

^fThe mean daily MPH dose was 0 mg in the behavioral therapy group, 23 mg in the community control, 31 mg in the combined medication management/behavior therapy group, and 38 mg in the medication management group.

^g229 completed treatment

^hBased on the MTA study sample and reporting on the 36-month naturalistic follow-up.