Table 3.

Genes significantly altered in response to Bacillus anthracis infection in murine lungs at 48 hr

GenBank ID	Gene Name	Function	FC
Up-regulated in Response to B. anthracis Infection
Inflammation and stress response
NM_020581	Angiopoietin-like 4 (Angptl4)	Response to hypoxia or starvation; negative regulation of apoptosis; positive regulation of angiogenesis	3.7
NM_009841	CD14 antigen (Cd14)	Inflammatory response; Immune response to LPS	3.5
AA796766	Metallothionein 2 (Mt2)	Nitric oxide mediated signal transduction	6.0
NM_011082	Polymeric immunoglobulin receptor (Pigr)	Secretion of IgA and IgM (apical surface of epithelial cells)	1.9
Metabolism
C85932	Crystallin, lamda 1 (Cryl1)	Fatty acid metabolism	2.6
Other
NM_020509	Resistin like alpha (Retnla)	Hormone signaling	3.3
Down-regulated in Response to B. anthracis Infection
Adhesion
BB477150	Protein tyrosine phosphatase, receptor type D (Ptprd)	Cell adhesion	−3.2
Cytoskeletal organization
BM900139	Actin binding LIM protein family, member 3 (Ablim3)	Cytoskeleton organization and biogenesis	−1.8
Growth and differentiation
BB428671	Platelet-derived growth factor, D polypeptide (Pdgfd)	Cell cycle regulation; proliferation	−2.1
NM_016686	Vascular endothelial zinc finger 1 (Vezf1)	Angiogenesis; endothelial cell development/differentiation; blood vessel morphogenesis	−2.5
Signal transduction
BB216074	Protein kinase, cAMP dependent regulatory, type II beta (Prkar2b)	Inhibition of PKA catalytic subunits	−1.7
Stress response
AB031049	REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (Rev3l)	DNA replication; DNA repair; response to DNA damage	−1.6
Transcription regulation
AI639846	Transcription factor 4 (Tcf4)	Regulation of transcription, DNA-dependent; development	−1.7

FC = fold-change

Negative sign (−) before fold-change value indicates down-regulation

Genes shown more than once were represented by more than one probe set on the array, and each was determined separately to be altered in response to Bacillus anthracis treatment