Table 6.
Genes significantly altered in response to Bacillus anthracis infection in murine spleens at 8 hr
| GenBank ID | Gene Name | Function | FC |
|---|---|---|---|
| Up-regulated in Response to B. anthracis Infection | |||
|
| |||
| Adhesion and migration | |||
| NM_025989 | Glycoprotein 2 (zymogen granule membrane) (Gp2) | Cell adhesion | 10.7 |
| NM_008411 | Integral membrane-associated protein 1 (Itmap1) | Substrate-bound cell migration, cell attachment to substrate | 4.5 |
| Digestive enzymes | |||
| NM_009669 | Amylase 2, pancreatic (Amy2) | Carbohydrate metabolism | 896.5 |
| NM_007919 | Chymotrypsin C (caldecrin) (Ctrc) | Proteolysis | 95.0 |
| AV076302 | Colipase, pancreatic (Clps) | Lipid catabolism | 586.3 |
| BI439550 | Elastase 3B, pancreatic (Ela3) | Proteolysis | 403.9 |
| AI326372 | Pancreatic lipase (Pnlip) | Lipid catabolism | 186.2 |
| Electron transport | |||
| AK007743 | Protein disulfide isomerase associated 2 (Pdia2) | Electron transport | 8.9 |
| Exocytosis | |||
| AV050299 | Syncollin (Sycn) | Calcium-sensitive regulation of exocytosis in exocrine tissues (putative) | 56.4 |
| Protein processing | |||
| NM_009258 | Serine protease inhibitor, Kazal type 3 (Spink3) | Endopeptidase inhibitor activity | 10.3 |
| Stress response | |||
| AV060866 | Phospholipase A2, group IB, pancreas (Pla2g1b) | Phospholipid metabolism; response to stress; cell proliferation | 26.5 |
| NM_009042 | Regenerating islet-derived 1 (Reg1) | Stress response; association with pancreatic inflammation | 89.3 |
|
| |||
| Down-regulated in Response to B. anthracis Infection | |||
|
| |||
| Apoptosis | |||
| NM_009344 | T-cell death associated gene (Tdag) | Apoptosis; FasL biosynthesis | −1.8 |
| Growth and differentiation | |||
| W77144 | Inhibitor of DNA binding 4 (Id4) | Positive regulation of cell proliferation | −2.2 |
| Immune response | |||
| BE634960 | CD48 antigen (Cd48) | T cell activation (putative) | −1.8 |
| BC018402 | Histocompatibility 2, D region locus 1 (H2-K1) | Antigen presentation | −2.4 |
| BC025447 | Immunoglobulin heavy chain (gamma polypeptide) (Igh-6) | Antigen processing and presentation;immunoglobulin mediated immune response; activation of MAPK activity | −1.8 |
| M74124 | Interferon activated gene 205 (Ifi205) | Immune response | −2.4 |
| NM_011558 | T-cell receptor gamma, variable 4 (Tcrg-V4) | Cellular defense response | −2.4 |
| Signal transduction | |||
| BB229616 | G protein-coupled receptor 171 (Gpr171) | G-protein coupled receptor protein signaling pathway | −2.8 |
| Transcription regulation | |||
| D45210 | Zinc finger protein 260 (Zfp260) | Regulation of transcription, DNA-dependent; development | −1.8 |
FC = fold-change
Negative sign (−) before fold-change value indicates down-regulation
Genes shown more than once were represented by more than one probe set on the array, and each was determined separately to be altered in response to Bacillus anthracis treatment