Table 7.
Genes significantly altered in response to Bacillus anthracis infection in murine spleens at 48 hr
| GenBank ID | Gene Name | Function | FC |
|---|---|---|---|
| Up-regulated in Response to B. anthracis Infection | |||
|
| |||
| Digestive enzymes | |||
| NM_009669 | Amylase 2, pancreatic (Amy2) | Carbohydrate metabolism | 1,042 |
| BI963522 | Chymotrypsin C (caldecrin) (Ctrc) | Proteolysis | 64.1 |
| BI439550 | Elastase 3B, pancreatic (ela3) | Proteolysis | 485.8 |
| AI326372 | Pancreatic lipase (Pnlip) | Lipid catabolism | 287.3 |
| Energy production | |||
| AK007743 | Protein disulfide isomerase associated 2 (Pdia2) | Generation of precursor metabolites and energy | 11.5 |
| Immune response and inflammation | |||
| NM_009883 | CCAATenhancer binding protein (CEBP), beta (Cebpb) | Immune response; inflammation; regulation of macrophage activation/differentiation | 2.6 |
| NM_009841 | CD14 antigen (Cd14) | Inflammation; response to LPS | 2.6 |
| NM_008176 | GRO1 oncogene (Gro1) (Cxcl1) | Immune response; inflammation | 4.5 |
| NM_010555 | Interleukin 1 receptor, type II (Il1r2) | Cell surface receptor linked signal transduction; inflammation | 2.5 |
| NM_011036 | Pancreatitis-associated protein (Pap) | Acute-phase response; inflammation | 16.2 |
| NM_009140 | Small inducible cytokine subfamily, member 2 (Scyb2) (Mip2) | Chemotaxis; inflammation | 4.4 |
| Metabolism | |||
| BB068040 | Glutamic pyruvate transaminase (alanine aminotransferase) 2 (Gpt2) | Metabolism | 2.2 |
| Pancreatic functions | |||
| BC020534 | Cholecystokinin A receptor (Cckar) | Pancreatic growth and enzyme secretion | 6.0 |
| AV050299 | Syncollin (Sycn) | Regulation of exocytosis | 89.0 |
| Protein processing and proteolysis | |||
| NM_025989 | Glycoprotein 2 (zymogen granule membrane) (Gp2) | GPI anchor binding | 25.1 |
| Stress response | |||
| NM_019738 | Nuclear protein 1 (Nupr1) | Cell growth in response to injury and proapoptotic stimuli (putative) | 3.5 |
| Transcription regulation | |||
| AI467599 | cAMP responsive element modulator (Crem) | Regulation of transcription, DNA-dependent | 6.3 |
|
| |||
| Down-regulated in Response to B. anthracis Infection | |||
|
| |||
| Growth and differentiation | |||
| BB770972 | Growth arrest-specific 2 like 3 (Gas2l3) | Cell cycle arrest | −2.3 |
| Immune response and inflammation | |||
| NM_053200 | Carboxylesterase 3 (Ces3) | Acyl-CoA metabolism; response to toxin | −1.9 |
| BE634960 | CD48 antigen (Cd48) | Immune response; T cell activation | −1.7 |
| BC025447 | Immunoglobulin heavy chain (gamma polypeptide) (Igh-6) | Activation of MAPK activity; immunoglobulin mediated immune response | −3.7 |
| M94350 | Immunoglobulin lambda chain (IgL) (Igl-V1) | Humoral immune response | −1.9 |
| BM239828 | Interferon-inducible GTPase (Iigp1) | Cytokine and chemokine mediated signaling pathway | −1.7 |
| NM_011558 | T-cell receptor gamma, variable 4 (Tcrg-V4) | Defense response | −1.6 |
| Metabolism | |||
| AW911807 | Guanine deaminase (Gda) | Hydrolase activity | −3.0 |
| Stress response | |||
| AK004608 | Heat shock 70kD protein 8 (Hspa8) | Regulation of progression through cell cycle; stress response | −2.0 |
| BB442713 | Mitogen-activated protein kinase kinase kinase kinase 5 (Map4k5) | Stress response | −1.5 |
| Transcription regulation | |||
| D45210 | Zinc finger protein (Zfp260) | Regulation of transcription, DNA-dependent | −1.8 |
| Transport | |||
| AI326108 | Intersectin 2 (Itsn2) | Endocytosis; regulation of Rho protein signal transduction | −2.1 |
FC = fold-change
Negative sign (−) before fold-change value indicates down-regulation
Genes shown more than once were represented by more than one probe set on the array, and each was determined separately to be altered in response to Bacillus anthracis treatment