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. 2008 Mar 12;131(6):1630–1645. doi: 10.1093/brain/awn016

Fig. 1.

Fig. 1

Regional variations in 6-CN-PiB fluorescence signal in Alzheimer's disease brain tissue. In the frontal cortex (FC), 6-CN-PiB histofluorescence is seen in numerous compact/cored and diffuse plaques, and in an isolated large blood vessel with amyloid angiopathy (A, arrow). Amorphous diffuse plaques in the hippocampus (HPC; B) are 6-CN-PiB positive, but have lower fluorescence intensity compared to cored/compact 6-CN-PiB labelled plaques. 6-CN-PiB histofluorescence is prominent in cores of neuritic plaques identified by the presence of tau-immunoreactive dystrophic neurites (C and D; double labelling of the same Alzheimer's disease frontal cortex tissue section with tau IHC; asterisk denotes a tissue landmark, matched plaques are marked by arrows). 6-CN-PiB and Aβ immunoreactivity co-localize in plaques in an Alzheimer's disease frontal cortex (E, F; tissue section double labelled for 6-CN-PiB histofluorescence and Aβ immuhistochemistry with 10D5 antibody). Both markers are seen exclusively in amyloid plaques. Scale bar = 175 µm (A), 100 µm (B–F).