Fig. 2.

6-CN-PiB histofluorescence is detectable in cloud-like diffuse plaques in the caudate nucleus of the striatum (STR; A). In the cerebellum (CRBL), 6-CN-PiB labelling is not appreciably above background levels (B), although the adjacent tissue sections processed for Aβ IHC (C, 10D5 antibody) and X-34 (D) show fleecy diffuse plaques in the molecular layer (ml) of cerebellar cortex (dotted line in B and D approximates the Purkinje cell layer). In the Purkinje cell layer, some isolated small compact plaques are detectable with both 6-CN-PiB and X-34 (inserts in B and D; gl, granular layer). Scale bar = 150 μm (A–D), 75 µm (Inset).