Table 1.

Co-localization of secretogranins II and III in human pancreatic endocrine cells. The amino acid sequences of the peptides used for production of antibodies are indicated

Immunoreactivity/cell type	Insulin	Glucagon	Somatostatin	Pancreatic polypeptide
N-terminal secretoneurin (SgII 154–165)	++++	++(+)	−	+(+)
C-terminal secretoneurin (SgII 172–186)	++++	+++	−	++
Secretogranin II (SgII 225–242)	++++	−	−	−
Secretogranin III (SgIII 348–361)	++++	++(+)	−	+(+)

–, no immunoreactive cells; +, fewer than 10% positive cells; ++, 10–50%; +++, 50–90%; ++++, virtually all cells are immunoreactive.

+(+) and ++(+), an apparent variation in frequency of immunoreactive cells between ‘+ and ++’ and ‘++ and +++’, respectively.