Figure 3.

Locomotor activity of H1R mutant mice. (a) Ambulation of the mouse was monitored every an hr for two days in a cage under a 12 hr light-dark cycle. Locomotor activity of last 24 hr was shown in every hr. Shaded area represents the dark period. Data are expressed as means ± SEM from eight mice. H1R mutant were significantly more active in the light period, and less active in the dark period of the light/dark cycle. (b) The ratio of ambulation during the light period to the locomotor activity during the 24 hr (L/24) and the dark period (L/D) are shown. Data are expressed as means ± SD from eight mice.