Table I.
Proteins involved in the Arabidopsis sRNA-regulated gene silencing pathways
| Protein | Locus | Protein Class/Function |
|---|---|---|
| AGO1 | At1g48410 | RNA slicer/core component of plant RISC |
| AGO4 | At2g27040 | RNA slicer/involved in the establishment phase of RdDM |
| AGO6 | At2g32940 | RNA slicer/rasiRNA-directed heterochromatin formation |
| AGO7 | At1g69440 | RNA slicer/tasiRNA biogenesis and juvenile-to-adult transition |
| CMT3 | At1g69770 | Methyltransferase/maintenance phase of RdDM |
| DCL1 | At1g01040 | RNase III/miRNA, natsiRNA, and tasiRNA biogenesis |
| DCL2 | At3g03300 | RNase III/natsiRNA biogenesis and viral defense |
| DCL3 | At3g43920 | RNase III/rasiRNA biogenesis and establishment phase of RdDM |
| DCL4 | At5g20320 | RNase III/tasiRNA biogenesis and viral defense |
| DRM2 | At3g17310 | Methyltransferase/establishment phase of RdDM |
| HYL1 | At1g09700 | dsRBP/miRNA and tasiRNA biogenesis |
| DRB4 | At3g62800 | dsRBP/miRNA and tasiRNA biogenesis |
| DRD1 | At2g16390 | SNF2-like chromatin-remodeling factor/establishment phase of RdDM |
| HEN1 | At4g29160 | sRNA-specific methyltransferase/sRNA biogenesis |
| HST | At3g05040 | Exportin-5 ortholog/miRNA exportation from nucleus |
| MET1 | At5g49160 | Methyltransferase/maintenance phase of RdDM methylation |
| NRPD1a | At1g63020 | DNA-dependent RNA polymerase/establishment phase of RdDM |
| NRPD1b | At2g40030 | DNA-dependent RNA polymerase/establishment phase of RdDM |
| NRPD2 | At3g23780 | DNA-dependent RNA polymerase/establishment phase of RdDM |
| RDR1 | At1g14790 | RNA-dependent RNA polymerase/viral defense |
| RDR2 | At4g11130 | RNA-dependent RNA polymerase/rasiRNA biogenesis |
| RDR6 | At3g49500 | RNA-dependent RNA polymerase/tasiRNA and natsiRNA biogenesis |
| SGS3 | At5g23570 | Coiled-coil protein/tasiRNA and natsiRNA biogenesis |