EGF and Epi modulation of BzATP-induced changes in cytosolic calcium (Cai) (A) and of BzATP-induced influx of ethidium bromide (B) in CaSki cells attached on filters. AU, Arbitrary units of fluorescence (Flu.) at 518/605 nm (excitation/emission). Insets, Means (± SD, three to five independent experiments) of the respective increases in Cai and in intracellular ethidium bromide Flu., 30 min after adding the BzATP. KN-62 was added at 100 nM, 15 min before adding BzATP. In both insets: *, P < 0.01 [Epi vs. C (control) and EGF groups]; **, P < 0.03 (EGF+Epi and KN-62 vs. Epi).