Table III.

Response criteria used in therapeutic trials.

Complete response	Absence of anemia
	No signs of hemolysis
	Disappearance of clinical symptoms of CAD
	Undetectable monoclonal serum protein
	No signs of clonal lymphoproliferation as assessed by bone marrow histology, immunohistochemistry and flow cytometry
Partial response	A stable increase in hemoglobin levels by at least 2.0 g/dl or to the normal range
	A reduction of serum IgM concentrations by at least 50% of the initial level or to the normal range
	Improvement of clinical symptoms
	Transfusion independence
No response	Failure to achieve complete or partial response
In order to qualify for any given response level, all criteria have to be fulfilled