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. 2007 Sep 4;4(3):209–217. doi: 10.1080/15476910701385570

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© 2007 Informa USA, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 2 — The AlloMap test score reflects differential gene expression in diverse regulatory pathways. The AlloMap test classifier for acute cellular rejection (ACR) consists of 20 genes, including 11 that inform on a variety of regulatory pathways and contribute to its 7 terms, which correspond to the expression of individual genes or the average expression levels of coordinately expressed genes termed metagenes. The classifier also includes 9 genes used for normalization of gene expression and quality control. Low AlloMap scores on a scale from 0 to 40, below the clinician-specified threshold, can be used to rule out ACR. Up-regulated (gray) and down-regulated (black) expression of genes, as assayed in peripheral blood mononuclear cells (PBMCs) by qPCR, contributes to the AlloMap score.