Skip to main content
. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Exp Eye Res. 2008 Jan 17;86(4):653–660. doi: 10.1016/j.exer.2008.01.010

Figure 3. TIMP-2 activity is partially protected against oxidant injury induced downregulation by E2 only in RPE cell lines containing ERβ.

Figure 3

ERKOα, ERKOβ and wildtype (data not shown) RPE cells were treated with E2 (1nM) for 24 hours before and after oxidant injury with MPO/H2O2 (I, injury) as described in methods. TIMP-2 activity (22kDa) was assessed on reverse zymography gels (inset), and densitometry performed. Shown is the data derived from ERKOα cell lines,**p<0.001 compared to vehicle (V), ##p<0.001 injury compared to injury +E2,