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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Exp Eye Res. 2008 Jan 17;86(4):653–660. doi: 10.1016/j.exer.2008.01.010

Figure 4. Injury-induced decrease of MMP-14 activity is prevented by E2 only in RPE cell lines containing ERβ.

Figure 4

Mouse wildtype (A) ERKOα (B) and ERKOβ (C) RPE cells were treated with 17β-estradiol (E2,1nM) for 24 hours prior to MPO/H2O2 treatment (I, injury). MMP-14 was determined with an activity kit as described in methods and data were normalized to the protein concentrations of each sample, *p<0.05 compared to vehicle (V), # p<0.05, ## p<0.001 injury compared to E2+injury, n=5 wildtype, n=3 ERKOα, n=4 ERKOβ. Data are expressed as percent of vehicle treatment.