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The amyloid seeding assay can detect PrPSc precipitated from human sCJD brain homogenates. (A) ThT fluorescence at 22 h for three AD controls and three sCJD samples. For both AD and sCJD, resuspended PTA pellets were diluted 1:20,000. (B–D) Titrations of the resuspended PTA pellets to determine sensitivity (**, P <0.01; ***, P <0.001).
