Figure 3.
Treatment of lymphoma-bearing mice with SCH66336. SCH66336 treatment for 3 days causes B cell lymphomas to regress in mice. The numbers of viable, isolated splenocytes are shown from unmanipulated C57BL/6 mice (Wild-type) or mice transplanted 18 days earlier with 106 lymphoma cells from an Eμ-Myc/BCRHEL/HEL transgenic mouse (Transplant Recipient). Mice were either left untreated (black bars), treated orally for the last 3 days with 1.56 mg SCH66336 every 12 hours (shaded bars), or treated orally for the last 3 days with vehicle alone every 12 hours (clear bar). Each group contains 4 mice and error bars represent the standard deviation for each group.